What is Sildenafil Citrate 100mg?
Sildenafil citrate 100mg fits into the pharmacological category of drugs known as phosphodiesterase 5(PDE5) inhibitors. PDE5 enzymes regulate the production of cyclic Guanosine Monophosphate (cGMP) enzyme. An adequate level of cGMP and PDE5 enzyme is necessary for proper erections during intercourse. In a person suffering from erectile dysfunction, there are abnormally high levels of PDE5 enzymes. These high levels of PDE5 result in more degradation of the cGMP enzyme. cGMP enzyme is an enzyme responsible for flow in the penile regions.
With more degradation of the cGMP enzyme, not enough blood flows into the organ. This causes erectile dysfunction in men. The whole idea behind PDE5 inhibitor medication is to control the excess production of PDE5 enzymes and control excess degradation of cGMP enzyme.
The medication is primarily used to achieve optimized productions of cGMP and PDE5 enzymes. The main concept behind these medications is to allow an adequate amount of blood flow into the organ and to allow blood flow in a regulated manner out of the organ during intercourse. Sildenafil Citrate 100mg works within a period of 40 minutes to 1 hour after its intake and the impact persists for around 4 to 6 hours. After consuming Sildenafil Citrate 100mg, a man is able to achieve proper penile erections and are able to overcome impotence during sexual acts.
What is the action mechanism of Sildenafil Citrate?
Soon after consuming this medication, the active ingredient starts inhibiting the production of enzymes, particularly known as phosphodiesterase 5 (PDE 5). PDE5 is the main cause of the constrained blood flow toward the penile area that leads to erectile dysfunction.
After confining the enzyme’s activity, sildenafil citrate increases the production of biochemical nitric oxide(NO) and an enzyme is known as guanylyl cyclase. Higher guanylyl cyclase levels sequentially increase the making of a strong vasodilator inside the human body known as cyclic Guanosine Monophosphate (cGMP).
The cGMP smoothens muscles of the penile area, widens the blood vessels in the penile region and then results in improved blood flow. This entire process of PDE5 enzyme inhibition, adequate cGMP enzyme production, the extra blood supply to the penile region and the expansion of blood vessels with the help of nitric acid results in a strong erection of the penile organ in men suffering from ED. Sildenafil Citrate 100mg tablets are very effective for treating erectile dysfunction. Men like to buy sildenafil citrate 100mg online as it is available at low prices online.
Things to Remember:-
Sildenafil citrate works effectively in most men. Like all other medications, there are certain things that one should remember before using Sildenafil Citrate pills:-
- The consumption of alcohol simultaneously can reduce the effectiveness of this medication. Alcohol affects the potential of this drug. In some patients, it can cause serious side effects too.
- Patients above 65 years of age may experience some delay as a result of Sildenafil Citrate.
- Fat-rich and Heavy meals should be avoided before consuming Sildenafil Citrate pills. The absorption rate of this medication falls in people who have consumed heavy means prior to consuming this tablet. This affects the potential of this medication.
- Medications such as rifampicin (utilized for curing tuberculosis) can alter blood pressure levels to serious levels; if taken along with this medication.
- Store the Sildenafil Citrate tablet in a cool and dry place. The best way is to keep these medications in air-tight containers in an isolated manner.
- Women and children should not use this medication.
- People having a history of heart, liver, and kidney disease should only consume this medication after consulting their physician.
- Diabetic patients should only use sildenafil citrate after having a prescription from a certified physician.